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BIOLOGY 426-Neuroscience DISCOVERIES IN NEUROBIOLOGY: HISTORY AND TECHNOLOGY

Section 002, Wednesdays, 3:00 pm - 3:50 pm
Multi-Disciplinary Science Bldg. Rm.155B

Dr. Robin L. Cooper
RLCOOP1@uky.edu
Office: Biology, rm 226
Tel: 257-5950
Office Hours: email for appt.
WWW Home page (go to)

The purpose of this interactive seminar program is engage in authentic scientific discovery related to neurobiology.

Resources: Papers and web links

FREE NEUROPHYSIOLOGY TEXT BOOK ON LINE (use for a review of basic concepts)
http://nba.uth.tmc.edu/neuroscience/m/s1/index.htm

Free background information on neuron morphology, conducting electrical, ionic bases of resting & action potential, and Synapse structure

Participation in conducting some analysis of synaptic responses will also be a focus in this course.

Research articles:

Ibraheem Murtaza (articles):

The first article briefly describes EEG what all it can be used for regarding a comatose patient. I plan to expand more on this and how EEG is used with sleep in the presentation.

The second article discusses a study where EEG was used to identify tissue that causes epilepsy in brain tumor patients for resection; the article talks about Invasive EEG such as Video EEG, Stereo EEG , and subdural EEG which I can talk about as types of EEG in my presentation.

42. EEG in coma and prognosis

Invasive EEG studies in tumor‐related epilepsy: When are they indicated and with what kind of electrodes?

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Squid giant axon chapter (10) on reserve for Lane Aldridge.

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Please view this link for AMY VANCE

https://www.youtube.com/watch?v=CPuIZsHZbOo&feature=youtu.be

Morgan Inks (ON LINE). ECHO 360 download to your computer and then open. It might not stream well on line as it is a large file. (50 MB)

Dalton House (The Importance of Behavioral Research and Experimental Design); On line large file MOV file 700 MB or use YOUTUBE link

Jacob Tow (visual system and the effects of blue light in aging ) ONLINE recording. Here Download. 41 MB

Week 1 (8/28): Liz Driehaus (CRISPR technology being applied to mice brains for the purposes of studying neuron differentiation/brain development) [PDF];

Week 2 (9/4): Collin Merkel (fMRI machines- brief history, explain how they work, and then would talk about how they have revolutionized brain diagnostics and advanced the field of neuroscience.)

Ibraheem Murtaza (brief history on EEG, explain how it works, and then show what it can diagnose and conclude with recent advancements with EEG and also talk about some cool stories EEG has been used in such as a recent article.... see left side)

Week 3 (9/11): Saisindhu Marella (History of Bioelectricity)

Dylan Ballard (DBS and its effectiveness as a last-resort OCD treatment to put on the website. https://journals-sagepub-com.ezproxy.uky.edu/doi/full/10.1177/0004867417731819)

Week 4 (9/18): Jacob Tow ("brain soup" and how professor Suzana Herculano-Houzel broke the myth of how many neurons are in the brain.)

Week 5 (9/25): Quantal variation in synaptic transmission (Robin ) Unless someone else pops up.

Week 6 (10/2): Saisindhu Marella (Optogenetics); Amy Vance (mirror neurons) & a 3rd talk by Matthew Barrett (transcranial magnetic stimulation).

Week 7 (Oct 9): Matthew Eastham {Research on polyphenols in the diet and how they might be protective of psychiatric disorders (or neurodegenerative disorders)}. Dylan Ballard (Rita Levi-Montalcini and Nerve Growth Factor); and Morgan Inks (ON LINE ).

Week 8 (Oct 16): Liz Driehaus (transverse myelitis); Dalton House (The Importance of Behavioral Research and Experimental Design); Hannah Tyger (Cochlear Implants)

Week 9 (Oct 23): NO CLASS

Jacob Tow (visual system and the effects of blue light in aging ) ONLINE recording

Dalton House (The Importance of Behavioral Research and Experimental Design). ONLINE recording.

Week 10 (Oct 30): Brianna Grimm (Pharmacogenomics); Collin Merkel (gut brain connection ppt file); Ibraheem Murtaza (Anesthetics)

Week 11 (Nov 6): Lane Aldridge (exercise and its effect on the brain); Matthew Eastham;( history presentation of Santiago Ramon y Cajal and his discoveries ); Amy Vance (vagus nerve stimulation).

Week 12 (Nov 13):Lane Aldridge (TBA); Matthew Barrett (TBA); Hannah Tyger (TBA)

Week 13 (Nov 20):Dalton House (TBA); Morgan Inks (TBA);Brianna Grimm (TBA)

No class-Thanksgiving -- Academic Holiday

Week 14 (Dec 4): Potentially no class unless someone forgets to show up in the listing above or bails the last minute. (If sick and miss - need an excuse and you can make an on line recording for the class to view)

Week 15 (Dec 11):LAST DAY .