REST: A Robust and Efficient Statistical Test
Katherine L. Thompson1 and Shili Lin2
1Department of Statistics, University of Kentucky, Lexington, KY 40536
2Department of Statistics, The Ohio State University, Columbus, OH 43210
katherine.thompson@uky.edu
The following code is an implementation of the method described in the following manuscript (available upon request):
Thompson, K.L. and S. Lin. 2016. A Robust and Efficient Statistical Test, Submitted.
About the Program
This code calculates the robust and efficient test (REST) statistic used to search for differentially expressed
genes among cancer and normal patients. The method includes a hypothesis test to search for for heterogeneous
differential expression in cancer samples that can guide the choice of an appropriate tuning parameter
used in the REST statistic.
Download:
Instructions to analyze the example data:
- In R, run the code in the script entitled 'restfunctions.R'
- Check to see that the data files are in the current working directory.
- In R, run the code in the script entitled 'rest_analysis_examples.R' to see the output from the
example data analysis.
Contact Information:
Questions or comments concerning this software can be e-mailed to me at katherine.thompson@uky.edu.