Home-country (South Korea)
University of Kentucky
Department of Biology
Robin L. Cooper
I am struggling with NMJ of Drosophila larva and crayfish in the lab to understand the properties of synaptic transmission.
With the neuromuscular junction (NMJ), I am investigating the effects of kainate action on both pre- and post synaptic receptors. the molecular sequence of the glutamate receptor on muscle in drosophila NMJ is similar to the kainate/AMPA receptor in verterbrate. Pharmacologically, however, it shows the differenct action for kainate.
If you are interested in what is happening, just click Here.
With the NMJ of crayfish walking leg, I suggest that there are at least two kinetic and distinguished vesicle pools within the presynaptic nerve terminal of the crayfish.
For this, I use the glutamate uptake blocker, DL-TBOA(dl-threo-beta-benzyloxyasparate) and serotonin (5-HT).
In the next step, I will use the bafilomysinn A which blocks the uptake of glutamate into vesicles.
As you cannot stop your finger from clicking Here, just let it go.