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BIOLOGY 426-Neuroscience DISCOVERIES IN NEUROBIOLOGY: HISTORY AND TECHNOLOGY

Section 002, Wednesdays, 3:00 pm - 3:50 pm
Multi-Disciplinary Science Bldg. Rm.155B

Dr. Robin L. Cooper
RLCOOP1@uky.edu
Office: Biology, rm 226
Tel: 257-5950
Office Hours: email for appt.
WWW Home page (go to)

The purpose of this interactive seminar program is engage in authentic scientific discovery related to synaptic transmission in central synapses as well as at neuromuscular junctions.

Resources: Papers and web links

FREE NEUROPHYSIOLOGY TEXT BOOK ON LINE (use for a review of basic concepts)
http://nba.uth.tmc.edu/neuroscience/m/s1/index.htm

Free background information on neuron morphology, conducting electrical, ionic bases of resting & action potential, and Synapse structure

Participation in conducting some analysis of synaptic responses will also be a focus in this course.

Research articles:

Why use flies ? (PDF 1, 2, 3, 4 flies and human disease )

Minis different than evoked...... Spontaneous and Evoked Release Are Independently
Regulated at Individual Active Zones PDF

Abdrakhmanov, M.M., Petrov, A.M., Grigoryev, P.N., Zefirov, A.L.(2013) Depolarization-induced calcium-independent synaptic vesicle exo- and endocytosis at frog motor nerve terminals. Acta Naturae 5(4):77-82. Abstract http://www.ncbi.nlm.nih.gov/pubmed/24455186

Week 1 (8/24): Chinni Suryadevara (Intro to chemical synapses ECHO record) & Samuel Wycoff (quantal transmission ECHO record)

Week 2 (8/31): Christina Hermanns (Use and misuse of optogentically stimulating neurons for transmission) (ECHO record)

Week 3 (9/7): Kaylee Hall (GABA transmission-ECHO) & Kate Davis (Gap Junctions-ECHO).

Week 4 (9/14) Carly Ballinger-Boone (Minis after stimulation-ECHO) Meghan Turner (The role of microglia in synaptic pruning-ECHO)

Week 5 (9/21) How nerve gas agents work on synapses (Nick- echo recording). Week 5 (9/21) Glial cleanup (Julie Rees- echo recording).

Week 6 ( 9/28) More on various forms of optogenetics (McNabb echo recording).

Week 7 (Oct 5) Robin on quantification of synaptic transmission.

Week 8 (Oct 12). Synapse formation and retrograde communication (Jennifier Costa voice only). Computational neuroscience ( Logan Hickey echo voice only),

Week 9 (Oct 19) Dopaminergic synapses (Paula Ortiz Guerrero, echo 360)

Week 10 (Oct 26) Snake neurotoxins PDF (Kate Davis) Quantal variation & Quantal variation PDF ( Carly Ballinger-Boone)

Week 11 (Nov 2) Synaptic pruning (PDF, PDF) (Nick, ECHO 360) & Computers and brains (PDF1, PDF2) ( Logan Hickey, ECHO360)

Week 12 (Nov 9) The Synaptic Role of Zinc (Meghan Turner, echo 360)

Week 13 (Nov 16) TBI and stem cells (Chinni echo360 ) & Addiction PDF (Christina Hermanns echo360) & metals in the brain ( Julie Rees echo360)

Week 14 (Nov 23) No class-Thanksgiving -- Academic Holiday

Week 15 (Nov 30) Synapses and Individuals with autism (2 papers PDF1, PDF2). (Paula Ortiz Guerrero, echo 360) and Vesicle recycling (PDF) (Kaylee Hall, echo 360) & importance of spontaneous events (PDF) (McNabb, echo 360)

Week 16 (Dec 7) LAST DAY. .synuclein inhibits vesicle release (pdf) (echo 360 Samuel Wycoff) & neuromuscular blockades such as vecuronium (PDF) ( echo 360 Jennifier Costa)